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KMID : 0388419960060010083
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Konkuk Journal of Medical Sciences
1996 Volume.6 No. 1 p.83 ~ p.92
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Prevalence of Helicobacter pylori Infection in Peptic Ulcer Disease and Its Eradication
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Abstract
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Recent studies have showed that there is a strong association between Helicobacter pylori and chronic gastritis, duodenal ulcer or gastric ulcer. The aims of this study are to evaluate the prevalence of H.pylori infection in chronic superficial
gastritis, duodenal ulcer and gastric ulcer patients by using rapid urease test(CLO(r)test) and to evaluate the efficacy of antibiotic therapy using colloidal bismuth subcitrate, metronidazole and amoxicillin in recurrent duodenal ulcer patients.
Rapid urease test was done in 346 patients with chronic superficial gastritis, 66 patients with duodenal ulcer and 50 patients with gastric ulcer. Triple therapy was done in 24 patients with recurrent duodenal ulcer and positive Helicobacter
pylori
infection. Laboratory tests were done prior and after treatment and 6 weeks later, re-examination was done to find the rate of ulcer healing and eradication of Helicobacter pylori.
@ES The results were as follows:
@EN 1) The prevalence of H.pylori infection in duodenal ulcer patients(89.4%) was significantly high compared with that of chronic superficial gastritis(56.4%) and gastric ulcer(64.0%).
2) There was no relation between infection and sex or age in chronic superficial gastritis.
3) Follow-up examination revealed that ulcer was healed in 19 patients(100%) and eradication rate of H.pylori was 94.7%.
4) Eighteen patients who were CLO(r) negative have been followed in 9 months and ulcer recurrence was not noted.
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KEYWORD
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